Nipple Sparing Mastectomy for Women with Breast Cancer Genes
Long-term Safety of Nipple Sparing Mastectomy in Women With High Penetrance Breast Cancer Susceptibility Genes in Breast Cancer
Recruiting
Observational Study
Breast Cancer Surgery
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 – 90
- Sex
- Female
- Study type
- Observational
- Participants needed
- 4,700 (estimated)
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital · Other
Who this trial is looking for
This trial is looking for women who carry certain gene mutations that increase their risk of breast cancer. Participants will be involved in checking the long-term safety of a surgery that preserves the nipple during breast removal.
Are You a Good Fit for This Trial?
You may be able to join if
- I am assigned female sex at birth
- I am 18 years or older
- I have a confirmed gene mutation in BRCA1, BRCA2, PALB2, TP53, CDH1, or PTEN
You may not be able to join if
- I have a history of breast cancer before genetic testing
- I have a history of ovarian cancer before genetic testing
- I have had both breasts removed before genetic testing
- I have a variant of uncertain significance without another gene mutation
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
Patients with a germline pathogenic variant (GPV) in high-penetrance breast cancer susceptibility genes who are considering risk reducing mastectomy (RRM) often strongly desire to keep their nipple areola complex but inquire as to whether it is safe to do so. Relative to traditional or skin sparing mastectomy (SSM) techniques, nipple sparing mastectomy (NSM) is associated with improved psychosocia…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Assigned female sex at birth
* Age 18 years or older
* Confirmed GPV in BRCA1, BRCA2, PALB2, TP53, CDH1 or PTEN identified on pre-symptomatic genetic testing
Exclusion Criteria:
* History of breast cancer prior to genetic testing
* History of ovarian cancer prior to genetic …
Contacts