COM701 for Relapsed Platinum Sensitive Ovarian Cancer

A Clinical Trial to Evaluate the Safety and Efficacy of COM701 in Relapsed Platinum Sensitive Ovarian Cancer

Recruiting Phase 1 Phase 2 Interventional Study
Ovarian Cancer Ovarian Cancer Recurrent
Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 and older
Sex
Female
Trial phase
Phase 1/2
Study type
Interventional
Purpose
Treatment
Participants needed
60 (estimated)
Sponsor
Compugen Ltd · Industry
Who this trial is looking for

This trial is looking for women with relapsed platinum sensitive ovarian cancer. Participants will receive an experimental treatment called COM701 and undergo regular health checks and tests over several visits.

Are You a Good Fit for This Trial?
Rules you out Active hepatitis B virusActive hepatitis C virusActive HIVSerious allergic reactions to monoclonal antibodies

You may be able to join if

  • I have relapsed platinum sensitive ovarian cancer, fallopian tube cancer, or primary peritoneal cancer.
  • I have completed at least 2 courses of platinum-containing therapy.
  • I have had at least 4 cycles of platinum-containing chemotherapy before joining the study and my tumor responded to treatment.
  • I have previously received maintenance therapy with bevacizumab or a PARP inhibitor and am not eligible or have chosen not to continue with those treatments.
  • I have recovered from side effects of previous treatments.

You may not be able to join if

  • I have had 4 or more lines of cytotoxic chemotherapy in total.
  • I am currently taking immunosuppressive doses of medications like steroids.
  • I have had previous treatments with any checkpoint inhibitors.
  • I have active liver metastases at the start of this chemotherapy.
  • I have had drainage of fluid in the abdomen during recent treatments.
  • I had a bowel obstruction in the last 6 weeks.
  • I have active central nervous system metastases.
  • I am currently pregnant, breastfeeding, or planning to become pregnant.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial
The goal of this clinical trial is to learn if the experimental antibody COM701 delays the progression of ovarian cancer in participants with Relapsed Platinum Sensitive Ovarian Cancer. It will also learn about the safety of COM701. The main questions the trial aims to answer are: * Does COM701, when used as a maintenance treatment, stop or slow the progression of ovarian cancer? * Does COM701 d…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Has relapsed platinum sensitive epithelial ovarian cancer, fallopian tube cancer or primary peritoneal cancer * Has completed at least 2 previous courses (i.e. lines) of platinum-containing therapy * For the last chemotherapy course prior to being randomized into the study, mu…
Contacts

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