Mechanism of Ketogenic Diet-Induced Hypercholesterolemia
Recruiting
N/A
Interventional Study
Hypercholesterolemia and Hyperlipidemia
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 39
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 100 (estimated)
- Sponsor
- Washington University School of Medicine · Other
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About This Trial
Very-low carbohydrate ketogenic diets can dramatically increase blood cholesterol levels, particularly in normal-weight people, for reasons that are not well understood. This study will enroll normal-weight adults, will identify "responders" who develop high cholesterol on a ketogenic diet, and will measure rates of production and removal of certain types of cholesterol-carrying particles called l…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. age ≥ 18 and \< 40 years
2. BMI ≥ 18.5 and \< 25.0 kg/m2
3. baseline serum LDL-c \< 150 mg/dL (\< 3.9 mmol/L)
4. baseline serum TG \< 100 mg/dL (\< 1.1 mmol/L)
5. HbA1c ≤ 5.6%.
Exclusion Criteria:
1. personal or family history of familial hypercholesterolemia
2. current use…
Contacts