No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
19 – 90
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
138 (estimated)
Sponsor
University of Nebraska · Other
Who this trial is looking for
This trial is looking for people with Parkinson's disease, essential tremor, or dystonia to see how deep brain stimulation affects attention and perception. Participants will complete tasks related to facial expressions before and after starting the stimulation.
Are You a Good Fit for This Trial?
Rules you outHistory of neurodegenerative disorder
You may be able to join if
I am aged 19 to 90 years.
I can provide signed informed consent.
I can express my judgments using a button press or a computer slider.
I have been diagnosed with Parkinson's disease, essential tremor, or dystonia.
I am scheduled to have a therapeutic deep brain stimulation device implanted.
I am willing to engage in tasks during an awake surgical procedure.
I can tolerate changes in deep brain stimulation.
You may not be able to join if
I have poor corrected visual acuity that prevents me from judging faces.
I cannot understand task instructions or complete the tasks.
I am not undergoing awake surgery for deep brain stimulation.
Deep brain stimulation has not helped my motor symptoms.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The goal of this observational and interventional study is to understand how therapeutic deep brain stimulation (DBS) affects attention, perception and cognition in participants with Parkinson's disease (PD) and non-PD movement disorders, including essential tremor (ET) and dystonia (DT). The main questions it aims to answer are:
* Does impaired control of attention and eye movement in PD alter h…
The goal of this observational and interventional study is to understand how therapeutic deep brain stimulation (DBS) affects attention, perception and cognition in participants with Parkinson's disease (PD) and non-PD movement disorders, including essential tremor (ET) and dystonia (DT). The main questions it aims to answer are:
* Does impaired control of attention and eye movement in PD alter how social cues are perceived and interpreted?
* Does therapeutic DBS improve or worsen attentional and perceptual deficits for social cues in PD, ET and DT?
* Can DBS be optimized to restore normal attentional control in PD while remaining an effective therapy for other aspects of the disorder.
* What do parts of the brain targeted by DBS contribute to the control of attention?
Using an eye tracking camera, investigators will study how participants with PD, ET and DT look at and perceive facial expressions of emotion before and after starting DBS therapy, in comparison to a group of healthy participants without ET, PD, DT or DBS. Participants with PD, ET and DT will see and rate morphed facial expressions on a computer screen in three conditions:
* Before starting DBS therapy (over approximately 1 hour).
* In the operating room, during the standard procedure to implant DBS electrodes, while the participant is awake (for no more than 15 minutes).
* After starting DBS therapy, with brief experimental changes of DBS stimulation level and frequency (over approximately 1 hour).
Trial Locations
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Eligibility Criteria
Inclusion Criteria
* All Participants (Aim 1):
* Ability and willingness to provide signed informed consent for this study
* Ability to express perceptual judgments through a button press or mouse- controlled computerized slider
* Age 19 - 90 years
* DBS Participants (Aim 1):
* Diagnosis …
Inclusion Criteria
* All Participants (Aim 1):
* Ability and willingness to provide signed informed consent for this study
* Ability to express perceptual judgments through a button press or mouse- controlled computerized slider
* Age 19 - 90 years
* DBS Participants (Aim 1):
* Diagnosis of idiopathic Parkinson's disease (PD), essential tremor (ET) or dystonia (DT).
* Scheduled for new implantation of a therapeutic DBS device targeted to subthalamic nucleus (STN), ventral intermediate nucleus of thalamus (VIM) or internal globus pallidus (GPi)
* Comparison Participants (Aim 1):
o Selection by age matching to participants in PD group
* Parkinson's disease (PD), essential tremor (ET) and dystonia (DT) Participants (Aim 2):
* Ability and willingness to provide signed informed consent for this study
* Ability to express perceptual judgments through a button press or mouse- controlled computerized slider
* Age 19 - 90 years
* Scheduled for awake DBS implantation with clinical micro-electrode recordings (MER)
* Willing and able to engage in tasks during an awake surgical procedure
* Parkinson's disease (PD), essential tremor (ET) and dystonia (DT) Participants (Aim 3):
* Ability and willingness to provide signed informed consent for this study
* Ability to express perceptual judgments through a button press or mouse- controlled computerized slider
* Age 19 - 90 years
* Willing to undergo acute manipulations of DBS
* Able to tolerate acute changes of DBS
Exclusion Criteria
* All Participants (Aim 1):
* Corrected visual acuity insufficient to perceptually judge face stimuli
* Inability to understand task instructions or complete task requirements
* DBS Participants (Aim 1):
o Insufficient therapeutic control of motor symptoms to engage in tasks requiring button press or use of a mouse to control a slider
* Healthy Comparison Participants (Aim 1):
o History of neurodegenerative disorder
* Parkinson's disease (PD), essential tremor (ET) and dystonia (DT) Participants (Aim 2):
* Corrected visual acuity insufficient to perceptually judge face stimuli
* Inability to understand task instructions or complete task requirements
* Not undergoing awake DBS implantation
* Uncorrected visual acuity insufficient to perceptually judge face stimuli
* Parkinson's disease (PD), essential tremor (ET) and dystonia (DT) Participants (Aim 3):
* Corrected visual acuity insufficient to perceptually judge face stimuli
* Inability to understand task instructions or complete task requirements
* Failure of DBS to achieve a therapeutic effect on motor symptoms
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