Ketamine for Pain and Mental Health in Trauma Patients
Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients
Recruiting
Phase 4
Interventional Study
Orthopedic Trauma Surgery Patients
Postoperative Pain
Opioid Use
Depression
Post-traumatic Stress Disorder (PTSD)
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 – 65
- Sex
- Any
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 90 (estimated)
- Sponsor
- Texas Tech University Health Sciences Center · Other
Who this trial is looking for
This trial is looking for adults with serious orthopedic injuries. Participants will receive either ketamine or standard anesthesia during their surgery and will report their recovery over time.
Are You a Good Fit for This Trial?
You may be able to join if
- I am between 18 and 65 years old.
- I am having surgery for a bone or muscle injury.
- My injury is severe (Injury Severity Score greater than 15).
- I can give my consent to participate in this study.
You may not be able to join if
- I am under 18 or over 65 years old.
- I have a known allergy to ketamine.
- I have tried ketamine before for depression or PTSD and it didn't work.
- I have severe psychiatric conditions.
- I have a history of dementia.
- I have glaucoma.
- I am currently in trauma-focused therapy or PTSD therapy that started in the last 3 months.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
The goal of this clinical trial is to learn if ketamine, given during surgery, can help improve recovery for adults with serious orthopedic trauma. The study will test whether ketamine reduces pain, lowers the need for opioids, and improves mental health outcomes like depression and post-traumatic stress disorder (PTSD).
The main questions it aims to answer are:
Does ketamine reduce pain after s…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Adults aged 18-65
* Undergoing acute operative fixation for musculoskeletal trauma
* Injury Severity Score (ISS) greater than 15
* Ability to provide informed consent (or consent provided by a legally authorized representative)
Exclusion Criteria:
* Age under 18 or over 65
*…
Contacts