Labetalol vs Nifedipine for Postpartum Hypertension
PEACE Trial: Postpartum Evaluation of Antihypertensive Cessation and Efficacy
Recruiting
Phase 4
Interventional Study
Postpartum Hypertension (PPHT)
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 – 64
- Sex
- Female
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 110 (estimated)
- Sponsor
- University of California, Los Angeles · Other
Who this trial is looking for
This trial is looking for postpartum patients with high blood pressure. Participants will take either labetalol or extended-release nifedipine while their blood pressure is monitored remotely.
Are You a Good Fit for This Trial?
You may be able to join if
- I am at least 18 years old.
- I delivered at the study institution at 28 weeks of pregnancy or later.
- My blood pressure is high after giving birth.
- I need to start taking medicine for high blood pressure.
- My healthcare team agrees to start one of the study medications.
You may not be able to join if
- I took medicine for high blood pressure before giving birth.
- I have allergies to nifedipine or labetalol.
- I have moderate to severe asthma.
- I have chronic obstructive pulmonary disease.
- I have heart failure.
- I have a severe heart block.
- I cannot provide consent in English.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
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About This Trial
This randomized controlled trial compares two common medications, labetalol and extended-release nifedipine, to determine which is more effective at managing postpartum high blood pressure. We hypothesize that extended-release nifedipine will better control blood pressure and reduce the need for continued medication beyond six weeks postpartum. The study will enroll 110 postpartum participants, ra…
Trial Locations
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Eligibility Criteria
Inclusion criteria:
Age ≥18 years Delivery at study institution at ≥28 weeks gestation Postpartum SBP \> 150 and/or DBP \> 100 OR 2 or more SBP \> 140 and/or DBP \> 90 within a 24-hour period Require initiation of an oral antihypertensive medication during postpartum hospital stay or within 7 days …
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