No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 50
Sex
Any
Study type
Interventional
Purpose
Other
Participants needed
40 (estimated)
Sponsor
University of Chicago · Other
Who this trial is looking for
This trial is looking for adults with Type 1 diabetes who use an insulin pump and a glucose monitoring device. Participants will be studied to see how sleep apnea affects blood sugar control.
Are You a Good Fit for This Trial?
Must not be takingSystemic glucocorticoidsAntipsychoticsThiazide diureticsBeta-blockersAminophyllineTheophylline
Rules you outProliferative retinopathyProlonged elevated liver enzymesKidney diseaseAnemiaAcute coronary syndromeStroke
You may be able to join if
I am between 18 and 50 years old
I have Type 1 diabetes and use an insulin pump
I use a continuous glucose monitor
My glucose management indicator is between 5.5 and 8.5%
I have been diagnosed with obstructive sleep apnea
You may not be able to join if
I use CPAP regularly as recommended by my doctor
I need oxygen or advanced breathing support while I sleep
I have had a 'fall-asleep' accident in the past 6 months
I do shift work
I have had severe low blood sugar in the past 3 months
I have gone to the emergency room for poor blood sugar control in the past 6 months
I have severe hypertension
I have any major health condition that affects my heart or lungs
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The purpose of the study is to investigate the role of sleep apnea in glycemic dysregulation in adults with Type 1 diabetes.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Age: 18 to 50 years old
* Type 1 Diabetes on insulin pump therapy and using a CGM device with an GMI (glucose management indicator) between 5.5 and 8.5% with hemoglobin in the normal range at screening
* OSA by home sleep apnea test
Exclusion Criteria:
* Regular and adherent…
Inclusion Criteria:
* Age: 18 to 50 years old
* Type 1 Diabetes on insulin pump therapy and using a CGM device with an GMI (glucose management indicator) between 5.5 and 8.5% with hemoglobin in the normal range at screening
* OSA by home sleep apnea test
Exclusion Criteria:
* Regular and adherent CPAP use per clinical guidelines
* Requiring oxygen or advanced positive airway pressure modalities during sleep
* Having a 'fall-asleep' or 'near miss' accident in the past 6-months
* Shift work
* Severe hypoglycemia (≥1 episode in the past 3 months or diagnosis of hypoglycemic unawareness)
* ≥1 trip to emergency room for poor glucose management in the past 6 months
* Proliferative retinopathy
* Fasting triglycerides \>400mg/dL,
* Liver transaminases \>2 times upper limit of normal,
* Renal transplantation or serum creatinine \>1.5 mg/dL
* Anemia (hemoglobin \<13.0g/dL in men or \<11.6g/dL in women)
* Acute coronary syndrome or stroke past 6 months
* Severe hypertension (blood pressure\>180/105 mmHg)
* Any other significant health condition: unstable angina, heart failure requiring hospitalization in the past 6 months, significant heart block or arrhythmias, NYHA Class\>2, pulmonary disease with dependence on oxygen or daily use of bronchodilators, active or chronic infection, thyroid disease and other endocrine disorders (e.g. Cushing syndrome, acromegaly)
* Recent major surgery
* Major psychiatric disorder
* Subjects will also be excluded if taking medications that can confound metabolic assessments including systemic glucocorticoids, antipsychotics, thiazide diuretics, beta-blockers, daily use of aminophylline or theophylline, or use of any immunosuppressant.
* Currently pregnant or trying to get pregnant or nursing
* Smoking, alcohol or illegal drug abuse
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