Metabolic Effects of Endogenous Bile Acids After Gastric Bypass Surgery
Recruiting
Early Phase 1
Interventional Study
Bariatric Surgery Candidate
Bile Acid, Elevated Serum
Glucose Metabolism Disorders
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Early Phase 1
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 18 (estimated)
- Sponsor
- Hvidovre University Hospital · Other
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About This Trial
Non-randomized, open-label, parallel-group clinical study evaluating the effects of endogenous bile acids on changes in plasma fibroblast growth factor-19 (FGF-19) and glucose metabolism by extended depletion of circulating bile acids using colesevelam as an experimental tool in subjects operated with gastric by-pass (RYGB).
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
Intervention group
* RYGB-operated ≥ 18 months prior to inclusion
* History of diabetes prior to RYGB (HbA1c ≥48 mmol/mol or use of antidiabetic medication)
* HbA1c \<58 mmol/mol on no antidiabetic medication or metformin alone
* Weight change \< ±3 kg for \>3 months at time of…
Contacts