Acupuncture Combined With PD-1/PD-L1 Inhibitors for Advanced Lung Cancer

Inclusion criteria: * Age 18-75 years; * ECOG/PS score of grade 0-1 and expected survival ≥ 3 months; * Non-small cell lung cancer AJCC lung cancer staging of stage IIIB-IV, or small cell lung cancer staging of extensive stage; * PD-L1 immunohistochemistry detection of tumor cell positive proportion score (TPS) \<50%; * Non-small cell lung cancer adenocarcinoma patients do not have EGFR-sensitive mutations, ALK fusions, ROS1 fusions, BRAFV600 mutations, NTRK fusions, RET fusions, MET14 skipping mutations, and amplified gene-driven mutations by genetic testing; * Patients with no previous systemic therapy/first-line treatment; * Patients suitable for chemotherapy combined with immunotherapy; * Traditional Chinese Medicine (TCM) diagnosis of Qi Depression; * Having at least 1 measurable tumor lesion (diameter \> 1cm) or lymph node short diameter ≥ 1.5cm; * Sign the informed consent form and voluntarily participate in this study. Exclusion criteria: * Combined with other primary malignant tumors; * Those who have contraindications to immunotherapy after basic assessment of immunotherapy; * Those with autoimmune diseases or those who need long-term treatment with systemic steroids or immunosuppressants; * Those with combined serious and uncontrolled primary diseases of heart, cerebrovascular, liver, kidney, hematopoietic system and so on; * Those with metal allergy or severe fear of needles; * Those who are pregnant or breastfeeding; * Those who are unable to cooperate to complete the assessment due to mental disorder, intellectual or language impairment; * Those with active severe infectious or inflammatory diseases; * Those who have received acupuncture treatment or other clinical trials within 1 month prior to randomization; * In the judgment of the investigator, persons who have a concomitant medical condition that seriously jeopardizes the safety of the participant or interferes with the completion of the study, or who are deemed to have other reasons for not being suitable for enrollment.