Organoid Models of Hepatocellular Carcinoma
Recruiting
N/A
Interventional Study
Hepatocellular Carcinoma
Organoids
Gut Microbiota
Tumor Microenvironment
System Disorders, Digestive
Surgery
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 150 (estimated)
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Other
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About This Trial
A promising tool to elucidate the molecular characteristics of HCC are patient-derived organoids (PDOs), three-dimensional cultures of cells that self-organise according to tissue-specific patterns and can be used to test the susceptibility of a specific tumour to anticancer agents. In this study, PDOs for HCC will be developed that closely resemble the tumour microenvironment in vivo and mimic th…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Capacity to express informed consent;
* Age ≥18 years;
* Suspected radiological diagnosis of HCC or diagnosis of HCC with indications for surgical resection.
Exclusion Criteria:
* Age \< 18 years;
* Contraindications to liver biopsy (ascites, platelets\<50,000, INR\>1.7);
* …
Contacts