A Rhinovirus Challenge Study to Investigate Exacerbations and Immune Responses in Bronchiectasis

Inclusion Criteria: * For healthy volunteers: 1\) Age 18 to 65 years. * For bronchiectasis study subjects: 1. Confirmed diagnosis of bronchiectasis aged 18-65 years with bronchiectasis severity index score of 0-8 . 2. For Pseudomonas colonised individuals, isolation of Pseudomonas aeruginosa in two or more cultures, at least 3 months apart in a 2-year period. Exclusion Criteria: * For healthy volunteers and bronchiectasis study subjects: 1. Any medical co-morbidity impacting the study in the opinion of the medical team 2. Current smoking history within last 12 months or ex smoking history \>5 pack years 3. Pre-existing serum neutralising antibodies to RV-A16 (strain to be used for challenge) 4. Close contact with infants or elderly individuals either at home or workplace 5. Pregnancy or breastfeeding * For bronchiectasis study subjects: 1\) Individuals with bronchiectasis secondary to cystic fibrosis, primary immunodeficiency, primary ciliary dyskinesia and allergic bronchopulmonary aspergillosis 2) Individuals with other significant chronic lung disease diagnoses (eg. interstitial lung disease) which would impact the study in the opinion of the medical team 4) FEV1 \< 50% predicted 8) Recent antibiotics for exacerbations within the preceding 6 weeks and prophylactic antibiotics (azithromycin or nebulised antibiotics) within preceding 4 weeks 9) Corticosteroid use (inhaled, nasal or systemic) within preceding 4 weeks.