No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
14 – 40
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
90 (estimated)
Sponsor
Seattle Children's Hospital · Other
Who this trial is looking for
This trial is looking for young people aged 14-40 with type 2 diabetes. Participants will engage in a short breathing exercise routine for 3 months to see how it affects their heart and kidney health.
Are You a Good Fit for This Trial?
You may be able to join if
I am aged 14-40
I have been diagnosed with type 2 diabetes for at least one year
My HbA1C level is less than 12%
You may not be able to join if
I have had type 2 diabetes for more than 18 years
My estimated glomerular filtration rate (eGFR) is less than 60 ml/min/1.73m2
My albumin-to-creatinine ratio (ACR) is greater than 2200mg/g
My blood pressure is greater than 160/100 mm Hg
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
High-resistance, short-duration inspiratory muscle strength training (IMST) is a novel lifestyle intervention involving 30 inhalations against a resistive load which requires only \~5 min/day and is thus ideal for youth with T2D (Y-T2D). Investigators seek to 1: assess changes in casual and 24-hr SBP, endothelial function, and arterial stiffness after 3 months of IMST vs. sham training in Y-T2D, 2…
High-resistance, short-duration inspiratory muscle strength training (IMST) is a novel lifestyle intervention involving 30 inhalations against a resistive load which requires only \~5 min/day and is thus ideal for youth with T2D (Y-T2D). Investigators seek to 1: assess changes in casual and 24-hr SBP, endothelial function, and arterial stiffness after 3 months of IMST vs. sham training in Y-T2D, 2: Define changes in eGFR andalbuminuria after 3 months of IMST vs. sham in Y-T2D, 3: Interrogate mechanisms of IMST by translational assessments of NO bioavailability, endothelial NO synthase (eNOS) activation, and ROS/oxidative stress, and determine the role of circulating factors.
Trial Locations
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Eligibility Criteria
Inclusion Criteria: Aged 14-40, have had T2D for a least one year, HbA1C less than 12%.
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Exclusion Criteria: Have had type II diabetes for more than 18 years, estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73m2 or Albumin-to-creatinine ratio (ACR) greater than 2200mg/g, blood …
Inclusion Criteria: Aged 14-40, have had T2D for a least one year, HbA1C less than 12%.
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Exclusion Criteria: Have had type II diabetes for more than 18 years, estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73m2 or Albumin-to-creatinine ratio (ACR) greater than 2200mg/g, blood pressure greater than 160/100 mm Hg.
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