Universal Chimeric Antigen Receptor T-Cell (UCAR T-cell) Therapy Targeting CD19/B Cell Maturation Antigen (CD19/BCMA) in Patients With r/r Neurological Autoimmune Diseases

Recruiting Early Phase 1 Interventional Study
Neuromyelitis Optica Spectrum Disorders Myasthenia Gravis Multiple Sclerosis Chronic Inflammatory Demyelinating Polyradiculoneuropathy Autoimmune Encephalitis
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 and older
Sex
Any
Trial phase
Early Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
12 (estimated)
Sponsor
Tianjin Huanhu Hospital · Other
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About This Trial

This is an open label, single-site, dose-escalation study in up to 12 participants with relapsed or refractory Neurological Autoimmune Diseases. This study aims to evaluate the safety and efficacy of the treatment with universal CD19/BCMA CAR T-cells.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Age ≥ 18 years. * Flow cytometry detected positive B cell CD19 or BCMA in the patient's peripheral blood. * Subjects with relapsed or refractory neurological autoimmune diseases, Including neuromyelitis optica spectrum disorders(NMOSD), myasthenia gravis(MG), multiple sclerosi…
Contacts

Jialing Wu

86-18622271026

wywjl2009@hotmail.com

CONTACT

Guanen Zhou

86-13920273016

tjzge@163.com

CONTACT