Oxalate and Citrate in Humans - Response to Citrate
Recruiting
N/AInterventional Study
Kidney StoneHealthy
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 70
Sex
Any
Study type
Interventional
Purpose
Prevention
Participants needed
24 (estimated)
Sponsor
University of Chicago · Other
Who this trial is looking for
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
This is a single-center study that aims to learn more about how two compounds found in food, oxalate and citrate, interact in the body and may influence a person's chances of forming kidney stones. The study will examine changes in urinary oxalate and citrate levels after participants consume potassium citrate.
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Eligibility Criteria
Inclusion Criteria:
Stone formers (SF):
* Age 18-70
* History of at least one calcium-based kidney stone
Non-stone formers (NSF):
* Age 18-70
* No history of kidney stone
* 24-hour urine oxalate within laboratory normal range (\<50 mg/day)
Exclusion Criteria:
History of primarily uric acid, cy…
Inclusion Criteria:
Stone formers (SF):
* Age 18-70
* History of at least one calcium-based kidney stone
Non-stone formers (NSF):
* Age 18-70
* No history of kidney stone
* 24-hour urine oxalate within laboratory normal range (\<50 mg/day)
Exclusion Criteria:
History of primarily uric acid, cysteine, or struvite stones
History of severe acid-base abnormality, very low (less than 100 mg/day) or very high (greater than 1500 mg/day) urine citrate
Any controls or stone former (SF) participants who cannot stop diuretic medication or alkali supplementation for the course of the study period
Chronic kidney disease (glomerular filtration rate \<75 milliliters per minute per 1.73 square meters \[mL/min/1.73 m²\])
Non-stone formers (NSF) and stone formers (SF) with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.
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