No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
20 – 75
Sex
Any
Study type
Interventional
Purpose
Supportive Care
Participants needed
125 (estimated)
Sponsor
Dartmouth-Hitchcock Medical Center · Other
Who this trial is looking for
This trial is looking for adults with multiple sclerosis who have memory and cognitive challenges. Participants will join virtual sessions to help improve their thinking skills over about six months.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 20 and 75 years old
I have been diagnosed with relapsing or progressive multiple sclerosis
I completed at least Grade 12 or have a GED
I can speak and understand English
I have cognitive and memory challenges
I have access to the internet
I have access to a telephone
You may not be able to join if
I have a current psychiatric disorder such as schizophrenia or bipolar disorder
I have another neurological disorder like epilepsy or a brain tumor
I have a diagnosed developmental attention or learning disorder
I had an MS relapse or ongoing steroid treatment in the last three months
I have significant vision problems that prevent me from reading or writing
I do not have access to the internet or a reliable telephone
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-MS to improve the quality of life and cognitive function in Service Members, Veterans and civilians who have multiple sclerosis with cognitive and memory problems (MS participants). This study will also assess the ability of the HOBSCOTCH-MS program to improve quality of life in caregivers of patients with…
The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-MS to improve the quality of life and cognitive function in Service Members, Veterans and civilians who have multiple sclerosis with cognitive and memory problems (MS participants). This study will also assess the ability of the HOBSCOTCH-MS program to improve quality of life in caregivers of patients with multiple sclerosis and to reduce caregiver burden. Enrolling with a Caregiver is optional for MS participants.
Investigators will compare two groups of MS participants and their Caregiver (enrolling with a Caregiver is optional): one who receives HOBSCOTCH-MS immediately (Group 1) and another group that will receive HOBSCOTCH-MS (Group 2) after a 3-month waiting period. Participants will be in the study for about 6 months total.
HOBSCOTCH-MS involves 45 to 60 minute one on one virtual sessions with a certified Cognitive Coach including a "pre" program session and 8 weekly sessions thereafter. Participants will learn about problem solving therapy and mindfulness or relaxation training. MS participants are asked to do short homework assignments and both MS and Caregiver participants are asked to keep a brief daily diary on a smart phone app. All participants complete study questionnaires or surveys at enrollment, 3 months later and at 6 months (at the end of the study).
After completing the intervention, MS Participants and their Caregivers may also participate in an optional one-time Key Informant Interview for qualitative analysis in an effort to further adapt and improve the HOBSCOTCH-MS in the future.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Inclusion Criteria - MS Participant
* Age 20 - 75 years
* Diagnosis of relapsing or progressive MS
* Education of at least Grade 12 or GED
* Fluent in English
* Subjective cognitive and memory challenges
* Internet access
* Telephone access
Inclusion Criteria -…
Inclusion Criteria:
* Inclusion Criteria - MS Participant
* Age 20 - 75 years
* Diagnosis of relapsing or progressive MS
* Education of at least Grade 12 or GED
* Fluent in English
* Subjective cognitive and memory challenges
* Internet access
* Telephone access
Inclusion Criteria - Caregiver Participant
* 20 years +
* Fluent in English
* Caregiver to a MS Participant
* Participant MS has given permission to Caregiver to enroll with them
* Internet access
* Telephone access
Exclusion Criteria:
* Exclusion Criteria MS Participant
* Current diagnosed psychiatric disorders (e.g., schizophrenia, bipolar disorder or substance use disorder).
* Other neurological disorder such as epilepsy, brain tumor, severe brain injury or mild to moderate brain injury with a history of 30 or more minutes' loss of consciousness, or other disorder that would confound the focus on MS
* Diagnosed developmental attention, learning, or intellectual disorder; sensory, motor, or physical disability that would prevent engagement with the intervention or render the person unable complete study outcome measures
* Exacerbation of MS symptoms (relapse) or ongoing steroid treatment within three months of study enrollment
* Significant visual impairment precluding reading or writing
* Lack of access to the technical resources (e.g., internet access, telephone) required for participation
Exclusion Criteria - Caregiver Participant
* Significant visual impairment precluding reading or writing
* No reliable telephone or internet access
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