REAMBERIN® 1.5% in Rehydration Therapy of Diabetic Ketoacidosis

Inclusion Criteria: * Signed Informed Consent * Male and female patients aged 18-75 years, inclusive. * Confirmed diagnosis of type 1 or type 2 diabetes mellitus * Established clinical diagnosis of DKA at the time of admission * Plasma glucose \> 13.9 mmol / l * Metabolic acidosis (venous blood pH \< 7.25) * Serum bicarbonate \< 18 mmol / l * Ketonuria ≥ ++ * Possibility of randomizing the patient within 2 hours from admission to the hospital. Exclusion Criteria: * Known hypersensitivity to any component of the study drug/standard therapy p * Blood pH ≤ 6.9 or standard bicarbonate level \<5 mmol/l * Previous use of other solutions containing reserve alkalinity carriers (acetate, lactate, malate, fumarate, etc). * Conditions requiring emergency surgical intervention * Abdominal surgeries in the last 14 days * Traumatic brain injury accompanied by cerebral edema. * Chronic treatment with steroids, atypical antipsychotics, cancer chemotherapy. * Acute kidney injury * Chronic kidney disease stage C5 * Liver injury (increase in alanine aminotransferase (ALT), aspartate aminotransferase (AST) levels by more than 5 times the established reference values). * Acute pancreatitis * Sepsis * Severe multiple or combined trauma * History of malignancy * Clinically significant cardiovascular diseases (acute coronary syndrome; acute cerebrovascular accident (CVA) or transient ischemic attack (TIA); chronic heart failure class III - IV according to the NYHA classification; severe uncontrolled arrhythmia). * Body mass index \>=40.0 * Alcohol abuse, drug use, drug use. * Other specific types of diabetes mellitus. * Previously diagnosed mental illness * Participation in another clinical trial or the use of drugs/dietary supplements containing succinic acid less than 30 days before inclusion in this study. * Pregnancy or breastfeeding. * SARS-CoV-2 infection * Low systolic blood pressure (BP) (≤70 mmHg) upon admission to hospital or at the time of inclusion in the study. * Contraindications to the infusion of REAMBERIN of 0.9% sodium chloride solution.