Blood Pressure Management through Genetic Risk Scores
Polygenic Risk Score Implementation and Stratification for Managing Blood Pressure
Recruiting
N/A
Interventional Study
Hypertension
Atherosclerotic Cardiovascular Disease
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 – 55
- Sex
- Any
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 300 (estimated)
- Sponsor
- University of Alabama at Birmingham · Other
Who this trial is looking for
This trial is looking for adults aged 18 to 55 with high blood pressure and poor heart health. Participants will receive either standard care or information about their genetic risk for high blood pressure, along with support to make healthier choices over a year.
Are You a Good Fit for This Trial?
You may be able to join if
- I am between 18 and 55 years old.
- I have been diagnosed with high blood pressure.
- I have poor heart health.
- I can undergo 24-hour blood pressure monitoring.
- I can give my consent to participate.
You may not be able to join if
- I have a history of heart disease.
- My body mass index (BMI) is under 18.5 or over 45.
- My blood pressure is too high at the start.
- I use more than two types of blood pressure medications.
- I am not high blood pressure based on 24-hour monitoring.
- I am pregnant or breastfeeding.
- My kidney function is low.
- I have significant mental health issues.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
In a multi-ethnic population, a genome-wide polygenic risk score (PRS) for systolic blood pressure (SBP), incorporating over one million common genetic variants, predicts blood pressure (BP) traits and the risk of adverse cardiovascular events beyond traditional risk factors. Delivering SBP PRS information to young and middle-aged adults with hypertension (HTN) and poor cardiovascular health (CVH)…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age 18 to 55 years (inclusive) at the time of screening.
* Diagnosis of hypertension defined by 2017 ACC/AHA guidelines, as evidenced by Resting office systolic blood pressure (SBP) of 130-160 mm Hg or Resting office diastolic blood pressure (DBP) of 80-100 mm Hg or Current us…
Contacts