Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain
Recruiting
N/AInterventional Study
Pain
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
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At a Glance
Age
18 – 60
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
60 (estimated)
Sponsor
The University of Texas Health Science Center, Houston · Other
Who this trial is looking for
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The purpose of this study is to assess thalamocortical (TC) connectivity during tonic pressure pain, to evaluate alpha activity during tonic pressure pain and to determine pressure pain ratings by using Electroencephalography (EEG), Functional Magnetic Resonance Imaging (fMRI), Transcranial Alternating Current Stimulation (tACS), sham and Transcranial random noise stimulation (tRNS)
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Eligibility Criteria
Inclusion Criteria:
* Meet the MRI / EEG screening criteria
* Fluent in English
Exclusion Criteria:
* Current or history of major medical, neurological, or psychiatric illness based on self-report
* History of cardiac, respiratory, or nervous system disease that, in the investigator's judgment, p…
Inclusion Criteria:
* Meet the MRI / EEG screening criteria
* Fluent in English
Exclusion Criteria:
* Current or history of major medical, neurological, or psychiatric illness based on self-report
* History of cardiac, respiratory, or nervous system disease that, in the investigator's judgment, precludes participation in the study because of a heightened potential for adverse outcome (for example: asthma or claustrophobia)
* History of head trauma
* Pregnant or lactating
* Presence of any contraindications to MRI scanning (for example: cardiac pacemaker, metal implants, claustrophobia, pregnancy, cannot lie still in fMRI scanner)
* Conditions making study participation difficult (e.g., paralysis, psychoses, or other severe psychological problems as per the judgment of a study investigator during Session 1)
* Active substance abuse disorders (based on subject self-report)
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