Prophylactic Transfusion In Pregnant in Women With Sickle Cell Disease
Recruiting
Phase 4
Interventional Study
Sickle Cell Disease
Pregnancy Related
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 and older
- Sex
- Female
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 50 (estimated)
- Sponsor
- Emory University · Other
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About This Trial
The goal of this study is to determine if there is a positive effect of prophylactic red blood cell (RBC) transfusion of leukoreduced, ABO, Rh (D/Cc/Ee) and Kell matched blood compared to standard of care on the number of episodes of acute sickle cell disease (SCD) manifestations or pregnancy-related complications requiring acute health care encounters (acute care/ER/Hospital visits) or resulting …
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Female
* Diagnosis of SCD of any genotype (i.e., HbSS, HbSC, HbSβ thalassemia)
* 18 Years and older
* Currently pregnant at 6 weeks through 20 weeks of gestation.
* Ability to understand the purposes and risks of the study and willingly give informed consent.
* For participant…
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