Intravenous rhTNK-tPA Before Stroke Thrombectomy in the Extended Time Window

Inclusion Criteria: 1. Age ≥18 years; 2. Acute ischemic stroke presenting within 4.5-24 hours of last known well; 3. No significant pre-stroke functional disability: for age \<80 years, pre-stroke modified Rankin scale (mRS) ≤2; for age ≥80 years, prestroke mRS ≤1; 4. Baseline NIHSS score ≥5; 5. Imaging criteria of BOTH: 1. Occlusion on CTA/MRA in one of the following vessels: M1/M2 segment of middle cerebral artery, A1 segment of anterior cerebral artery, V4 segment of vertebral artery, basilar artery, or P1 segment of posterior cerebral artery. For A1, or P1 occlusions, vessel diameter must be ≥0.75 mm; 2. For anterior circulation occlusion: CTP/MRP demonstrating mismatch ratio ≥1.8, absolute mismatch volume ≥15 mL, and ischemic core volume \<70 mL; OR have a mismatch between the presence of an abnormal signal on MRI diffusion-weighted imaging and no visible signal change on FLAIR. For posterior circulation occlusion: pc-ASPECTS score ≥6. 6. Plan to received endovascular thrombectomy; 7. The patient or their legal representative provides written informed consent. Exclusion Criteria: 1. Intracranial hemorrhage confirmed by CT/MRI; 2. Already received intravenous thrombolytic after index stroke.; 3. Pregnancy or lactation; 4. Concurrent participation in other investigation drug clinical trials; 5. Arterial tortuosity or other vascular anomalies precluding endovascular access to target vessel; 6. Pre-existing neurological/psychiatric disorders interfering with neurological assessment; 7. Space-occupying intracranial tumors (except small meningiomas ≤3 cm); 8. Intracranial aneurysm or arteriovenous malformation; 9. Terminal illness with life expectancy \<6 months; 10. Anticipated inability to complete follow-up assessments.