Heart CT Imaging to Detect Early Coronary Artery Disease in First-Degree Relatives With High or Low Lipoprotein(a) Identified Through Family Screening

In order to be eligible to participate in this study in the elevated Lp(a) subgroup, a subject must meet all of the following inclusion criteria: * Man or woman ≥50 years of age; * Lp(a) level ≥ 150 nmol/L; * Identified as having elevated Lp(a) through Lp(a) family cascade screening at the Amsterdam UMC Vascular Medicine outpatient clinic; * Able and willing to provide informed consent; * Able to comply with study requirements. In order to be eligible to participate in this study in the Low Lp(a) subgroup, a subject must meet all of the following inclusion criteria: * Man or woman ≥50 years of age; * Lp(a) level \< 50 nmol/L; * Identified as having elevated Lp(a) through Lp(a) family cascade screening at the Amsterdam UMC Vascular Medicine outpatient clinic; * Able and willing to provide informed consent; * Able to comply with study requirements. A potential subject who meets any of the following criteria will be excluded from participation in this study (both subgroups): * Renal insufficiency, defined as eGFR \< 30 ml/min * History of ASCVD (acute coronary syndrome, history of myocardial infarction, stable or unstable angina pectoris or coronary or other arterial revascularization, stroke, transient ischemic attack or peripheral artery disease including aortic aneurysm, all of atherosclerotic origin) * History of atrial fibrillation * Prior and current use of statins * Any other treatment or clinically relevant condition that could interfere with the conduct or interpretation of the study in the opinion of the investigator * Unable or unwilling to provide informed consent * Unable to comply with study requirements.