Molecular and Cellular Basis of Severe Forms of Dengue in Sickle Cell Patients
Recruiting
Observational Study
Dengue (Virus); Fever, Sandfly
Sickle Cell Disease
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 6 – 25
- Sex
- Any
- Study type
- Observational
- Participants needed
- 130 (estimated)
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe · Other
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About This Trial
Dengue virus (DENV) belongs to the genus of Flavivirus transmitted by the mosquito Aedes aegypti and is responsible for an infectious disease associated with different forms and severities such as dengue hemorrhagic fever or shock syndrome. Several recent reports have shown that sickle cell patients exhibited an increased risk of developing severe forms of dengue episodes compared to non-sickle ce…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* patients with SS or SC SCD or controls with hemoglobin AA
* diagnosis of SCD performed by electrophoresis or HPLC in a reference laboratory for hemoglobinopathies
* patients older than 6 years and younger than 25 at inclusion
* clinically in a steady state at inclusion (withou…
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