A Dose-escalation Study Followed by a Dose Optimal Study to Evaluate the Safety and Efficacy of CID-103 in Adults With Chronic Immune Thrombocytopenia

Inclusion Criteria: 1. Male or female individuals aged 18 to 65 years at time of signing of ICF. Disease-related. 2. Diagnosed with ITP that has persisted for ≥ 3 months, diagnosed in accordance with The American Society of Hematology 2019 Guidelines for Immune Thrombocytopenia or the Updated International Consensus Report on the Investigation and Management of Primary Immune Thrombocytopenia (as locally applicable). 3. Diagnosis of ITP supported by a prior response to an ITP treatment (other than a thrombopoietin receptor agonists \[TPO-RA\]) that achieved a platelet count of ≥ 30 x 10\^9/L and a doubling of baseline measurement. 4. Has received at least two lines of SOC systemic treatment (i.e., corticosteroids and one other agent). 5. Has a mean platelet count ≤ 35 x 10\^9/L on at least two measurements at least one week apart during screening. 6. If receiving standard background treatment for ITP, treatment should be stable in dose and frequency for at least four weeks prior to first dose of CID-103. 7. Adequate organ function. 8. Contraception: Female participants must either be non-pregnant or not breastfeeding and must have a negative pregnancy test. Male and female participants must meet the contraceptive requirements. Exclusion Criteria: 1. Prior treatment with any anti-CD38 agent, or has been treated with anti-Bruton's tyrosine kinase (BTK), neonatal Fc receptor (FcRn) antagonist or complement inhibitor within three months prior to first dose of CID-103. 2. Use of IV immunoglobulin, subcutaneous immunoglobulin or anti-D immunoglobulin treatment within four weeks of screening. 3. Treatment with rituximab or splenectomy within the three months prior to first dose of CID-103. 4. Use of anticoagulants or any drug with antiplatelet effect (such as aspirin) within three weeks before screening. 5. Receiving other concurrent investigational therapies or have received investigational therapies within four weeks of the first dose of CID-103 or five half-lives (if shorter). 6. Active hemolytic anemia. 7. Diagnosed with severe chronic obstructive pulmonary disease (COPD), Global Initiative for Chronic Obstructive Lung Disease (GOLD Stage 3 or 4) or asthma. 8. Has been diagnosed with myelodysplastic syndrome or other active malignancy. 9. Known / clinically significant amyloidosis. 10. Has a history of any thrombotic or embolic event within six months before screening. 11. A history or evidence of cardiovascular risk including left ventricular ejection fraction \< 50%, clinically significant uncontrolled ventricular arrhythmia, acute coronary syndrome history, coronary angioplasty or stenting within six months, current ≥ Class III congestive heart failure (NYHA guidelines), and treatment refractory hypertension. 12. Clinically significant medical history or ongoing chronic illness. 13. Known active infection with hepatitis B (HBV) (surface antigen) or infection with hepatitis C (HCV) in absence of sustained virologic response. 14. History of known or suspected immunosuppression. 15. Known active infection with human immunodeficiency virus (HIV) and CD4+ T cell count \< 350/μL. 16. Karnofsky Performance Status ≤ 70.