POTS-FLOW: Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS

Recruiting N/A Interventional Study
Postural Orthostatic Tachycardia Syndrome (POTS) Healthy
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Healthy Volunteers Welcome You do not need to have the condition being studied to take part.
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At a Glance
Age
18 – 50
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
30 (estimated)
Sponsor
University of Copenhagen · Other
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About This Trial

This study will describe the interplay between the gut hormones GIP and CCK and their regulation of blood flow to the large vessels in patients with Postural Orthostatic Tachycardia Syndrome (POTS) and GIP, CCK and GLP-1 in healthy. This is addressed by hormone infusions during MR-scans of the abdomen and intake of oral glucose.

Trial Locations
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Eligibility Criteria
Inclusion Criteria POTS patients: * Previously diagnosed with POTS in tilt test or active stand-test (either newly diagnosed within last 3 months or in new tilt test/active stand test during screenings visit) * Reproducible orthostatic intolerance with raise in HR on \>30 bpm when standing within 1…
Contacts

Sophie W Nielsen, MD

+ 45 27 26 79 94

sophie.nielsen@sund.ku.dk

CONTACT

Lærke S Gasbjerg, MD, PhD

+45 25 34 68 94

lsg@sund.ku.dk

CONTACT