No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
125 (estimated)
Sponsor
Duke University · Other
Who this trial is looking for
This trial is looking for people with Alzheimer's disease or smell problems. Participants will provide tissue samples from their nasal cavity.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 18 and 80 years old.
I have symptoms of Alzheimer's disease.
I have normal cognitive function but positive Alzheimer's biomarkers.
I can understand and sign the consent form.
You may not be able to join if
I have advanced Alzheimer's or dementia.
I have an allergy to Afrin or Tetracain HCL.
I have active rhinosinusitis symptoms.
I have a history of sinonasal diseases affecting the biopsy area.
I have Parkinson's disease.
I cannot complete the nasal endoscopy procedure.
I cannot read or speak English.
I cannot provide legally effective consent.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This research study aims to investigate the function of the olfactory lining in the nasal cavity and its potential alterations in both healthy and diseased conditions. The olfactory lining is involved in the sense of smell.
The purpose of this study is to collect tissue from the nasal cavity.
Trial Locations
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Status
Eligibility Criteria
Group 1: Alzheimer's study
Inclusion Criteria:
* Between the ages of 18 and 80
* Pre-clinical AD (this cohort consists of subjects who have normal cognitive testing and function, but have positive AD biomarkers);
* Symptomatic AD (a confirmed diagnosis of Alzheimer's or dementia who are capable of…
Group 1: Alzheimer's study
Inclusion Criteria:
* Between the ages of 18 and 80
* Pre-clinical AD (this cohort consists of subjects who have normal cognitive testing and function, but have positive AD biomarkers);
* Symptomatic AD (a confirmed diagnosis of Alzheimer's or dementia who are capable of understanding and signing the consent document)
Exclusion Criteria:
* Advanced Alzheimer's/dementia
* Self-reported or known allergy to Afrin or Tetracain HCL (or related class of drugs)
* Active Rhinosinusitis symptoms
* Other known sinonasal disease history that would preclude biopsy (i.e prior sinus or skull base surgery directly impacting this anatomic region, sinonasal neoplasm in this anatomic region, olfactory cleft polyps)
* Parkinson's disease
* Unable or willing to complete the nasal endoscopy procedure.
* Unable to read or speak English
* Unable to provide legally effective consent
Group 2: Act-seq study or Non-AD controls
Inclusion Criteria:
* Age 18 years or older
* Patients being seen for rhinology or olfactory disorders
* Patients having unrelated endoscopic nasal surgery
Exclusion Criteria:
* Self-reported or known allergy to Afrin or Tetracain HCL (or related class of drugs)
* Unable or willing to complete the nasal endoscopy procedure
* Unable to read or speak English
* Unable to provide legally effective consent
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