Nifedipine vs Enalapril for Postpartum Hypertension

Postpartum Evaluation of Nifedipine and Enalapril for Hypertension

Recruiting Phase 4 Interventional Study
Hypertension in Pregnancy
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
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Review the details below, then apply to join this clinical trial.

At a Glance
Age
19 and older
Sex
Female
Trial phase
Phase 4
Study type
Interventional
Purpose
Treatment
Participants needed
850 (estimated)
Sponsor
Nebraska Methodist Health System · Other
Who this trial is looking for

This trial is looking for women who have high blood pressure after giving birth. Participants will take either nifedipine or enalapril to see how well these medications manage their blood pressure and prevent hospital readmission.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am 24 weeks pregnant or more.
  • I have high blood pressure related to my pregnancy.
  • I am being admitted for delivery, either by cesarean or vaginal.
  • I have chronic high blood pressure.

You may not be able to join if

  • I have a medical reason that prevents me from taking nifedipine or enalapril.
  • My heart rate is less than 60 beats per minute or more than 110 beats per minute.
  • I speak a language other than English.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial
This is an open label, randomized controlled trial designed to compare nifedipine and enalapril in the management of postpartum hypertension. This is an equivalence study- meaning it is not expected one medication is better than the other. Nifedipine has been shown to be better than another common blood pressure medicine, labetalol, for postpartum hypertension but enalapril which is also used worl…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: 1. admitted for delivery by cesarean or vaginal delivery 2. 24 weeks gestation or greater 3. Pregnancy related hypertension(HTN) or chronic hypertension. Pregnancy related hypertension will be defined during the study as either a systolic blood pressure ≥140mmHg or diastolic blo…
Contacts

Todd Lovgren, MD

14028151970

todd.lovgren@nmhs.org

CONTACT

Joshua Dahlke, MD

14028151970

joshua.dahlke@nmhs.org

CONTACT