An Exploratory Study on Gene Methylation Detection of Colorectal Cancer

Inclusion Criteria: 1. Sample Source: Hospital physical examination, outpatient, and inpatient patients; 2. Patient Information: Patient information (such as age, hospital ID number, gender, clinical diagnosis, colonoscopy and pathology results) is traceable; 3. Age Requirement: ≥ 40 years old; 4. Sampling Time Requirement: Stool and plasma samples must be collected within 3 months prior to colonoscopy (stool samples are preferred). Exclusion Criteria: 1. Unclear Sample Collection Information: Samples with unclear collection time, or stool samples not collected within 3 months prior to colonoscopy, or samples with incomplete clinical information that cannot be traced; 2. Non-compliance with Sample Requirements: Samples that do not meet the collection and storage requirements; 3. History of Disease: Subjects with a history or treatment of colorectal cancer (CRC) or advanced precancerous lesions; 4. Insufficient Sample Volume: Samples with insufficient volume that cannot meet the requirements of the assessment system testing; 5. Hereditary Diseases: Subjects with a diagnosis or family history of the following diseases:Familial adenomatous polyposis (FAP), including attenuated FAP and Gardner syndrome;Hereditary nonpolyposis colorectal cancer syndrome (HNPCC or Lynch syndrome);Other hereditary cancer syndromes, including but not limited to Peutz-Jeghers syndrome, MYH-associated polyposis (MAP), Turcot syndrome (or Crail syndrome), Cowden syndrome, juvenile polyposis, neurofibromatosis, or familial proliferative polyposis (FAP); 6. Inflammatory Bowel Disease (IBD): Subjects with a diagnosis or personal history of IBD, including chronic ulcerative colitis and/or Crohn's disease; 7. Cronkhite-Canada Syndrome: Subjects with a diagnosis of Cronkhite-Canada syndrome.