Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories
Recruiting
Phase 2
Interventional Study
Preeclampsia
Gestational Hypertension
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Female
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 204 (estimated)
- Sponsor
- Massachusetts General Hospital · Other
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About This Trial
The hypertensive disorders of pregnancy (preeclampsia and gestational hypertension) are associated with increased long-term maternal risk of developing cardiovascular disease. Recent evidence suggests that activation of the mineralocorticoid receptor promotes ongoing susceptibility to hypertension in women following hypertensive disorders of pregnancy. In addition, women with overweight/obesity ar…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Females aged ≥18 years
* HDP (gestational hypertension or preeclampsia) without pre-pregnancy chronic hypertension
* BMI ≥25 kg/m2 prior to pregnancy or in the first trimester
* Requirement for antihypertensive medication within one week of delivery
* Ability to provide inform…
Contacts