PEEP Titration in Lung Protective Ventilation for CABG
Lung Protective Ventilation and Driving Pressure Guided PEEP Titration in CABG Surgery
Recruiting
Observational Study
Peep Titration in Lung Protective Ventilation
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 70
Sex
Any
Study type
Observational
Participants needed
86 (estimated)
Sponsor
Kocaeli University · Other
Who this trial is looking for
This trial is looking for patients who are scheduled for a certain type of heart surgery. Participants will be monitored to see how two different methods of a breathing technique affect their recovery during surgery.
Are You a Good Fit for This Trial?
You may be able to join if
I am scheduled for elective on-pump coronary artery bypass graft surgery.
I am between the ages of 18 and 70.
I have an ASA physical status of II or III.
You may not be able to join if
I have an ejection fraction below 35%.
I did not consent to participate in the study.
I am undergoing emergency surgery.
I am allergic to the anesthetic drugs used.
I have undergone lung resection.
I have a history of mechanical ventilation in the 2 months before surgery.
I have had total circulatory arrest and deep hypothermia.
I have obstructive sleep apnea syndrome requiring long-term ventilation assistance.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Our aim in this study is to compare fixed and individualized PEEP (driving pressure guided ) application for intraoperative lung protective ventilation in patients undergoing on-pump CABG surgery.
Researcher aimed to compare the effects of two different PEEP application methods on intraoperative hemodynamics, respiratory mechanics, and gas exchange, as well as postoperative extubation times, resp…
Our aim in this study is to compare fixed and individualized PEEP (driving pressure guided ) application for intraoperative lung protective ventilation in patients undergoing on-pump CABG surgery.
Researcher aimed to compare the effects of two different PEEP application methods on intraoperative hemodynamics, respiratory mechanics, and gas exchange, as well as postoperative extubation times, respiratory complications (atelectasis, need for non invasive mechanical ventilatıon, need for re-entubatıon) length of stay in the intensive care unit, and discharge times.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Patients scheduled for elective on-pump coronary artery bypass graft surgery via median sternotomy
* Patients between the ages of 18 and 70
* ASA (American Society of Anesthesiologists) physical status classification II-III
Exclusion Criteria:
* Patients with an ejection fra…
Inclusion Criteria:
* Patients scheduled for elective on-pump coronary artery bypass graft surgery via median sternotomy
* Patients between the ages of 18 and 70
* ASA (American Society of Anesthesiologists) physical status classification II-III
Exclusion Criteria:
* Patients with an ejection fraction below 35%
* Patients who did not consent to participate in the study
* Patients undergoing emergency surgery
* Patients who are allergic to the anesthetic drugs used
* Patients who have undergone lung resection
* Those with a history of mechanical ventilation in the 2 months before surgery
* Patients who have undergone total circulatory arrest and deep hypothermia
* Patients with obstructive sleep apnea syndrome requiring long-term ventilation assistance
* Morbid obesity (Body Mass Index\>35kg/m2)
* Patients with refractory hypoxemia (arterial oxygen saturation below 88% despite 100% oxygen inhalation)
* COPD (FEV1\<70%)
* Patients with chronic renal failure (serum creatine\>1.8 mg/dl)
* Anemia (Hg\<10 gr/dl)
* Patients who have had an intraaortic balloon pump placed.
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