Affect of Melatonin on Sleep and Cognition in Cirrhosis

Recruiting N/A Interventional Study
Hepatic Encephalopathy Covert Hepatic Encephalopathy Cirrhosis Sleep Disturbances and Insomnia
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
18 (estimated)
Sponsor
Weill Medical College of Cornell University · Other
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About This Trial
The goal of this clinical trial is to learn the affect of melatonin on sleep, cognitive function, and quality of life (QoL) in patients with cirrhosis and a complication called hepatic encephalopathy (HE). The main questions this study aims to answer are: * Does taking melatonin increase REM sleep, an important part of healthy sleep that is reduced in cirrhosis? * Does taking melatonin improve co…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Cirrhosis with clinically significant portal hypertension or decompensation defined by Baveno VII criteria \[de Franchis R et al 2022\] * Adults over age 18 * CHE (defined by PHES≤ -4) or previously diagnosed HE * Disturbed sleep, with Pittsburgh Sleep Quality Index (PSQI) ≥5 …
Contacts

Adam Buckholz, MD MS

646-962-5483

apb9012@med.cornell.edu

CONTACT