Exercise Study for Healthy and Prehypertensive Adults
Difference in Acute Responses of Vascular Function to Moderate-intensity and High-intensity Interval Training in Healthy and Prehypertensive Individuals
Recruiting
N/AInterventional Study
Prehypertension (Elevated Blood Pressure) or HypertensionHealthy
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
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At a Glance
Age
18 – 50
Sex
Any
Study type
Interventional
Purpose
Screening
Participants needed
45 (estimated)
Sponsor
University of Ljubljana · Other
Who this trial is looking for
This trial is looking for healthy adults and those with slightly elevated blood pressure. Participants will take part in different types of exercise sessions while we measure how their blood vessels respond.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 18 and 50 years old
I have a BMI under 30
I have normal blood pressure or have been diagnosed with prehypertension
I am sedentary or not very active
I do not take any prescribed medication
I do not have any chronic diseases
You may not be able to join if
I have high blood pressure or am not within the optimal blood pressure range
I am very active
I have low blood pressure
I have a chronic disease
I take prescribed medication
I have had a lower extremity injury in the last six months
I have gone through menopause
I am pregnant or do not have a normal menstrual cycle
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
In this study, the investigators will evaluate acute changes in vascular function measures after moderate-intensity continuous and high-intensity interval exercise in healthy and prehypertensive individuals. Participants will be subjected to three separate visits: control condition (30 min rest), moderate-intensity continuous exercise, and high-intensity interval exercise. The investigators will m…
In this study, the investigators will evaluate acute changes in vascular function measures after moderate-intensity continuous and high-intensity interval exercise in healthy and prehypertensive individuals. Participants will be subjected to three separate visits: control condition (30 min rest), moderate-intensity continuous exercise, and high-intensity interval exercise. The investigators will measure aerobic capacity using a cardiopulmonary exercise test (CPET) using indirect gas-exchange to derive subsequent exercise intensity and maximal oxygen uptake. The investigators will evaluate different measures of vascular function (Pulse-wave velocity, Flow-mediated slowing, microvascular function) before and after each condition.
The study will involve two groups of participants: healthy individuals and prehypertensive individuals. The investigators aim to establish the reliability and validity of less-established methods of vascular function assessment (flow-mediated slowing and microvascular function) against established measures (pulse-wave velocity). The acute response of vascular function to different exercise intensities has not yet been thoroughly researched using the aforementioned measures in individuals with similar characteristics to the proposed study cohort.
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Eligibility Criteria
Inclusion Criteria:
Normotensive participants inclusion criteria:
* 18 - 50 years of age, BMI \< 30, blood pressure (BP) within the optimal range according to the latest ESH guidelines (\< 120 mmHg systolic and/or \< 80 mmHg diastolic BP)
* Sedentary or low active according to the Global Physical …
Inclusion Criteria:
Normotensive participants inclusion criteria:
* 18 - 50 years of age, BMI \< 30, blood pressure (BP) within the optimal range according to the latest ESH guidelines (\< 120 mmHg systolic and/or \< 80 mmHg diastolic BP)
* Sedentary or low active according to the Global Physical Activity Questionnaire (GPAQ) (Armstrong \& Bull, 2006; Lim et al., 2012)
* No prescribed medication and absence of chronic diseases
Inclusion criteria for prehypertensive individuals:
* 18 - 50 years of age, BMI \< 30
* Diagnosed prehypertension by a clinican from the Hypertension clinic, University clinical centre of Ljubljana using established criteria
* Sedentary or low or moderately active according to the Global Physical Activity Questionnaire (GPAQ)
* No prescribed medication and absence of chronic diseases
Exclusion Criteria:
* Blood pressure out of the optimal range (normotensives)
* High level of phyisical activity (moderate or high active according to GPAQ)
* Hypotension
* Chronic diseases
* Prescribed medication
* Lower extremity injury in the last six months
* Menopause
* Absence of normal menstrual cycle
* Pregnancy
* Smoking
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