Predictive Value of CRP, Albumin, CAR, and mGPS in Treatment Outcomes of DLBCL
Recruiting
Observational Study
DLBCL - Diffuse Large B Cell LymphomaMarkers of Inflammation
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
18 – 65
Sex
Any
Study type
Observational
Participants needed
40 (estimated)
Sponsor
Ain Shams University · Other
Who this trial is looking for
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This observational study evaluates the predictive value of systemic inflammatory markers-CRP, albumin, CRP-to-albumin ratio (CAR), and modified Glasgow Prognostic Score (mGPS)-in patients with diffuse large B-cell lymphoma (DLBCL) receiving R-CHOP chemotherapy. The study examines associations with treatment response, toxicity, and clinical characteristics.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age ≥ 18 years and ≤ 65 years
* Pathologically confirmed, treatment-naïve diffuse large B-cell lymphoma (DLBCL)
* Any stage of disease (nodal or extra-nodal), with or without B symptoms
* Scheduled to receive standard systemic treatment (R-CHOP)
* ECOG performance status 0-2
*…
Inclusion Criteria:
* Age ≥ 18 years and ≤ 65 years
* Pathologically confirmed, treatment-naïve diffuse large B-cell lymphoma (DLBCL)
* Any stage of disease (nodal or extra-nodal), with or without B symptoms
* Scheduled to receive standard systemic treatment (R-CHOP)
* ECOG performance status 0-2
* Baseline normal:
* Complete blood count (CBC)
* Hepatitis viral markers
* Liver and renal function tests
* Urine analysis
* Echocardiogram
* Additional investigations to exclude current infection if clinically indicated
Exclusion Criteria:
* History of other concurrent or previous malignancies
* Relapsed or refractory DLBCL
* Uncontrolled comorbid conditions that may interfere with study participation, including:
* Diabetes mellitus
* Autoimmune diseases
* Active infections
* Chronic inflammatory diseases
* Cardiac dysfunction
* Liver cell failure
* Pregnant females
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