Lidocaine Infusion for Chronic Migraines

Bilateral Middle Meningeal Artery Lidocaine Infusion for Chronic Debilitating Migraines

Recruiting Phase 2 Interventional Study
Migraine
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 75
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Treatment
Participants needed
40 (estimated)
Sponsor
Northwell Health · Other
Who this trial is looking for

This trial is looking for adults with severe chronic migraines that don't improve with standard treatments. Participants will receive a targeted lidocaine treatment to help reduce headache pain and frequency.

Are You a Good Fit for This Trial?
Rules you out Chronic subdural hematomaSymptomatic peripheral arterial diseaseActive chronic pain syndromesMajor psychiatric disorder with significant depression

You may be able to join if

  • I am aged between 18 and 75 years old.
  • I have very severe migraines at least 15 days a month for over 3 months.
  • I have not found relief from at least 3 migraine preventive treatments.
  • I score 6 or 7 on a migraine severity scale.
  • I experience moderate to severe headache pain more than half the time.
  • I have been diagnosed with chronic daily headache for at least 12 months.
  • I report inadequate response to my current migraine treatment.
  • I have been on stable medications for the last 3 months.

You may not be able to join if

  • I have started a new migraine preventative treatment in the last 3 months.
  • I am allergic to lidocaine.
  • I have had a severe allergy to iodinated contrast dye.
  • I have any significant brain condition recently shown on brain imaging.
  • I have had a stroke or heart attack in the past 3 months.
  • I have a history of severe kidney problems.
  • I have had abnormal heart test results in the past 3 months.
  • I am pregnant or planning a pregnancy during the study.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial

The main purpose of this study is to evaluate the effectiveness of a new treatment in improving chronic migraine symptoms. This treatment involves a targeted lidocaine infusion into blood vessels in the skull to numb pain receptors, potentially leading to improvements in chronic migraine intensity, frequency, and duration.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: 1. Adults aged 18 to 75 years with a very severe to extremely severe medically refractory Chronic Daily Headache (CDH). 1. Chronic: as defined by the International Headache Society Classification ICHD 3 (\>15 headache days a month for a period of at least 3 months) 2. Med…
Contacts

Jeffrey Katz, MD

5163257000

jkatz2@northwell.edu

CONTACT