No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
30 (estimated)
Sponsor
Larissa University Hospital · Other
Who this trial is looking for
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The goal of this study randomized single-center crossover study is to evaluate the impact of asymmetrical versus symmetrical nasal high flow (NHF) therapy on work of breathing (WOB). The main question it aims to answer are:
1\. Does the asymmetrical NHF interface improve the work of breathing compared to the symmetrical NHF interface? Researchers will compare the symmetrical NHF interface to the …
The goal of this study randomized single-center crossover study is to evaluate the impact of asymmetrical versus symmetrical nasal high flow (NHF) therapy on work of breathing (WOB). The main question it aims to answer are:
1\. Does the asymmetrical NHF interface improve the work of breathing compared to the symmetrical NHF interface? Researchers will compare the symmetrical NHF interface to the symmetrical NHF interface to see if the the asymmetrical interface has a greater impact on the work of breathing.
Participants will :
1. receive NHF via both interfaces (FiO₂ 0.21, 50 L/min) for 15 minutes, in random order, with esophageal pressure monitoring and bioelectrical impedance analysis performed.
2. baseline characteristics will me monitored throughout the interventions
3. Esophageal pressure and minute ventilation will be monitored.
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Eligibility Criteria
Inclusion Criteria:
1. age ≥18 years old
2. absence of symptoms and signs of respiratory failure (SpO2\>95% at FiΟ2 0.21)
Exclusion Criteria:
1. pregnancy
2. SpO2\<94% at FiΟ2 0.21
3. neuromuscular disease
4. contraindications to esophageal pressure monitoring (e.g., uncontrolled coagulopathy, es…
Inclusion Criteria:
1. age ≥18 years old
2. absence of symptoms and signs of respiratory failure (SpO2\>95% at FiΟ2 0.21)
Exclusion Criteria:
1. pregnancy
2. SpO2\<94% at FiΟ2 0.21
3. neuromuscular disease
4. contraindications to esophageal pressure monitoring (e.g., uncontrolled coagulopathy, esophageal disease, nasal trauma, allergy to local lidocaine)
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