MASTER is a single-center, patient and investigator-blinded, Randomized Controlled Trial (RCT) to compare the efficacy of Maraviroc, a C-C chemokine receptor 5 (CCR5) antagonist, against placebo regarding motor function and motor learning skills in the first 3 months after ischemic stroke.
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Eligibility Criteria
Inclusion Criteria:
* Informed consent as documented by signature
* ≥18 years at time of signing of informed consent
* Acute ischemic stroke.
* Stroke onset \< 7 days from randomization.
* Contralateral, unilateral, incomplete upper limb paresis, incl. :
* FMA-UE \< 63/66
* Residual voluntary finge…
Inclusion Criteria:
* Informed consent as documented by signature
* ≥18 years at time of signing of informed consent
* Acute ischemic stroke.
* Stroke onset \< 7 days from randomization.
* Contralateral, unilateral, incomplete upper limb paresis, incl. :
* FMA-UE \< 63/66
* Residual voluntary finger extension (VFE) of \> 10 degrees
Exclusion Criteria:
* Pregnancy/lactation or positive pregnancy test in women of childbearing age
* Pre-stroke handicap (mRS \> 2)
* Diseases affecting motor function (e.g., Parkinson's Disease, Amyotrophic Lateral Sclerosis (ALS))
* Participation in another study with investigational medicinal product within 30 days preceding and during the present study
* Enrolment of the investigator, his/her family members, employees, or other dependent persons
* Known hypersensitivity to Maraviroc, Mannitol, peanuts, or soy
* History of significant liver disease, hepatitis, elevated liver function tests (\> 1.5 upper limit of normal)
* History of significant renal disease or End Stage Renal Disease/dialysis, acute renal injury, Creatinine Clearance (CrCl \< 30ml/min/1.73m2)
* Patients with cardiovascular comorbidities and risk for orthostatic hypotension
* HIV infection
* Concomitant use of strong CYP3A4 inhibitors or inducers
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