Different Methods of Aerosolized Polymyxin B Inhalation for Treating Carbapenem-Resistant Gram-Negative Bacterial Pneumonia.
Recruiting
Observational Study
Carbapenem-Resistant Enterobacteriaceae Infection
Pneumonia - Bacterial
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 – 90
- Sex
- Any
- Study type
- Observational
- Participants needed
- 144 (estimated)
- Sponsor
- Fujian Medical University Union Hospital · Other
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About This Trial
Study Design:
A randomized, open-label, parallel-group clinical trial comparing the efficacy and safety of jet nebulization versus vibrating mesh nebulization of sulfate polymyxin B in mechanically ventilated patients with carbapenem-resistant Gram-negative bacterial pneumonia.
Participants:
144 patients (72 per group) will be enrolled from December 2023 to December 2025.
Interventions:
Group…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Pneumonia diagnosed per Chinese Thoracic Society criteria (radiographic + clinical evidence).
* Sputum culture-confirmed carbapenem-resistant Gram-negative bacteria susceptible to polymyxin B.
* ≥3 days of aerosolized polymyxin B therapy.
* Mechanically ventilated with an arti…
Contacts
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