The investigators will conduct two-arm randomized controlled trials (RCTs) comparing effects of UPLIFT vs. enhanced usual care and PACES vs. enhanced usual care, respectively, on quality of life, depressive symptoms and seizures over 12 months in NYU patients with epilepsy.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Adults (≥18 years)
* English-speaking (UPLIFT and PACES) or Spanish-speaking (UPLIFT only).
* Diagnosed with epilepsy for at least one year
* Able to understand the informed consent and provide consent
* Elevated depressive symptoms - Patient Health Questionnaire-9 (PHQ-9) sco…
Inclusion Criteria:
* Adults (≥18 years)
* English-speaking (UPLIFT and PACES) or Spanish-speaking (UPLIFT only).
* Diagnosed with epilepsy for at least one year
* Able to understand the informed consent and provide consent
* Elevated depressive symptoms - Patient Health Questionnaire-9 (PHQ-9) score ≥10; applies to UPLIFT only
Exclusion Criteria:
* Severe depressive symptoms (score of ≥20 on PHQ-9)
* Active suicidal ideation (score of ≥1 on PHQ-9 item #9 or otherwise reported during screening)
* Active psychotic disorder (psychiatric diagnosis and/or antipsychotic medications in the electronic health records (EHR)
* Significant cognitive impairment (indicated in the EHR or evident during screening)
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