Focused Ultrasound Neuromodulation in Patients With Treatment-Resistant Depression
Recruiting
N/A
Interventional Study
Treatment-Resistant Depression
Treatment-resistant Depression (TRD)
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 – 65
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 20 (estimated)
- Sponsor
- Sunnybrook Health Sciences Centre · Other
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About This Trial
The goal of this clinical trial is to evaluate the safety and initial effectiveness of Magnetic Resonance-guided focused ultrasound neuromodulation using the Next Generation Dome Helmet (NGDH) device in patients with treatment-resistant depression. This is a prospective, single-arm, non-randomized study.
Participants will:
* Undergo two focused ultrasound treatment sessions targeting nodes of th…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Deemed to have the capacity to provide informed consent.
2. Aged between 18 and 65 years.
3. Diagnosis of major depressive disorder (MDD) according to DSM-5 criteria.
4. Total score \>20 on the Hamilton Depression Rating Scale (HAMD-17).
5. On a stable regimen of psychiatric …
Contacts