Spectacles or Atropine for Myopia Control

Inclusion Criteria: 1. Age 5 years to \<12 years at time of enrollment. Children within 4 weeks of their 12th birthday are not eligible. 2. Refractive error meeting the following by cycloplegic autorefraction: * Myopia of 0.75D to 6.00D SER and at least 0.75D in both principal meridians of each eye * Astigmatism \<2.50D both eyes * Anisometropia \<1.50D SER 3. Investigator has confirmed the following regarding best-corrected distance visual acuity (VA) in habitual spectacles or trial frames using the investigator's preferred VA testing method: * VA is age normal in both eyes1,2 * 5-6 years: approximately 20/32 or better, ≤ 0.24 logMAR, ≥ 73 letters * 7-12 years: approximately 20/25 or better, ≤ 0.14 logMAR, ≥ 78 letters * Interocular difference ≤2 logMAR lines (0.2 logMAR) or ≤ 10 letters 4. Wearing spectacles by parent report ≥90% of waking hours ≥30 days duration before enrollment. For children who meet all other inclusion criteria but whose single-vision spectacles are broken or lost within the last 90 days, enrollment can proceed as long as the child was wearing their single-vision spectacles ≥90% of waking hours ≥30 days before the spectacles were broken or lost. 5. Gestational age ≥ 32 weeks. 6. Birth weight \>1500 g. 7. Parent(s) and assenting child understand the study procedures and are willing to accept randomization to atropine 0.05%, HAL lenses, atropine combined with HAL lenses, or placebo (i.e., neither active treatment). 8. Parent is willing to participate in a 2- to 4-week run-in phase using nightly artificial tear eyedrops in both eyes. 9. Family can return in 2 to 4 weeks for possible randomization. 10. Child is willing to refrain from contact lenses for the duration of the study. 11. Parent has a phone (or access to a phone) and is willing to be contacted by the clinical site staff. 12. Relocation outside of the area of an active PEDIG site within the next 32 months is not anticipated. Exclusion Criteria: 1. Current or previous pharmacologic or light therapy used for myopia treatment. 2. Current or prior contact lens wear more than 7 days in the past 12 months 3. Current or previous use of bifocals, progressive-addition lenses, multi-focal contact lenses, or focus- or contrast-modifying spectacle lenses. 4. Current or previous use of orthokeratology, rigid gas permeable, or other contact lenses used to slow myopia progression. 5. Current or previous myopia control treatment or other uses of atropine, pirenzepine or other anti-muscarinic agents. 6. Known atropine allergy 7. Known allergy to shellfish 8. Abnormality of the cornea, lens, central retina, iris, or ciliary body 9. Current constant or intermittent strabismus (phorias are acceptable) 10. Verified history of amblyopia or nystagmus. 11. Prior strabismus, intraocular, or refractive surgery 12. Down syndrome or cerebral palsy 13. Diseases known to affect accommodation, vergence, or ocular motility (e.g., multiple sclerosis, Graves' disease, myasthenia gravis, diabetes mellitus) 14. Any condition that, in the judgment of the investigator, could influence refractive error development. 15. Existing conditions in the opinion of the investigator that may affect the long-term health of the eye or require regular pharmacologic treatment that may adversely interact with study medication (e.g., JIA, glaucoma, pre-diabetes). 16. Inability to comprehend and/or perform any study-related procedures. 17. Individuals who are pregnant, lactating, or intending to become pregnant within the next 30 months. a. A negative urine pregnancy test at randomization and the 6-, 12-, 18-, and 24-month follow-up visits will be required for individuals who have experienced menarche (at least one menstrual cycle). 18. Immediate family member (spouse, biological or legal guardian, child, sibling, parent) who is investigative site personnel directly affiliated with this study or who is an employee of the Jaeb Center for Health Research. 19. Sibling of, or living in the same household as, another child who is concurrently enrolled in the study.