Long-term Study of ORX750 for Narcolepsy and Hypersomnia

A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia

Recruiting Phase 2 Interventional Study
Narcolepsy Type 1 Narcolepsy Type 2 Idiopathic Hypersomnia
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 65
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Treatment
Participants needed
90 (estimated)
Sponsor
Centessa Pharmaceuticals (UK) Limited · Industry
Who this trial is looking for

This trial is looking for individuals diagnosed with narcolepsy or idiopathic hypersomnia who have completed a prior study. Participants will take ORX750 and help researchers understand its long-term safety and effectiveness.

Are You a Good Fit for This Trial?

You may be able to join if

  • I have been diagnosed with narcolepsy type 1 or type 2 or idiopathic hypersomnia.
  • I completed the full treatment period in the previous study.

You may not be able to join if

  • I have developed a new disease or disorder that prevents me from continuing.
  • I cannot stop taking medications that are not allowed for this study.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial

This study is a long-term extension (LTE) of the parent Study ORX750 0201, and will provide long-term open-label safety, tolerability, and efficacy of ORX750 in participants with narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), and idiopathic hypersomnia (IH).

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Diagnosis of narcolepsy (NT1 or NT2) or IH who was eligible for and completed the full treatment period in the eligible parent study ORX750-0201 (CRYSTAL-1) * Is willing and able to adhere to additional protocol requirements Exclusion Criteria: * Development of any new disea…
Contacts

Orexin Centessa Program Lead

617-468-5770

ORX750-LTE@centessa.com

CONTACT