Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies
Recruiting
Phase 4
Interventional Study
Cesarean Delivery
Postpartum Comfort
Postpartum Pain
Post-operative Pain
NSAIDs
Acetaminophen (D000082)
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 16 and older
- Sex
- Female
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 825 (estimated)
- Sponsor
- Thomas Jefferson University · Other
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About This Trial
Cesarean delivery is a commonly performed surgical procedure associated with worse postpartum pain when compared to vaginal birth. Uncontrolled postpartum pain is associated with increased neonatal and maternal risks. Multimodal non-opioid pain medications, including acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) are the preferred first-line therapies. There is no standard practi…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* \>/= 34 weeks gestation
* Singleton pregnancy
* Delivery via cesarean section under regional anesthesia
Exclusion Criteria:
* Contraindication to acetaminophen or NSAIDs
* Current or history of opioid use or misuse
* Intrauterine fetal demise
* Major congenital anomaly
* Con…
Contacts