White Matter Distortion and Dementia Biomarkers in Normal Pressure Hydrocephalus (NPH)
Recruiting
Observational Study
Normal Pressure Hydrocephalus
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 60 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 100 (estimated)
- Sponsor
- Imperial College London · Other
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About This Trial
Idiopathic Normal Pressure Hydrocephalus (iNPH) is a progressive condition of the elderly that results in severe disability. iNPH can dramatically respond to Cerebral spinal fluid(CSF)-shunting where excess ventricular fluid is diverted from the brain. Not all patients with iNPH respond to CSF-shunting however. The reasons for this are uncertain.
Aim 1: To understand if specific nerve pathways (w…
Trial Locations
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Eligibility Criteria
Group 1 (communicating hydrocephalus):
Inclusion Criteria:
* Adult patients \>60
* With gait apraxia
* With or without cognitive impairment
* Urinary dysfunction
* Communicating Hydrocephalus
Exclusion Criteria:
* Asymptomatic hydrocephalus
* High pressure-hydrocephalus
* Serious head injury wit…
Contacts