Pulmonary Rehabilitation in Advanced Lung Cancer Survivors
Recruiting
Phase 2Interventional Study
Non-small Cell Lung Cancer Stage IIINon-small Cell Lung Cancer Stage IVNon-small Cell Lung CancerLung Cancer
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Supportive Care
Participants needed
85 (estimated)
Sponsor
Case Comprehensive Cancer Center · Other
Who this trial is looking for
This trial is looking for people who have advanced non-small cell lung cancer and experience some shortness of breath. Participants will receive either pulmonary rehabilitation or standard care for eight weeks to see if their breathing improves.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with advanced non-small cell lung cancer (NSCLC).
I am an adult, 18 years or older.
I rate my breathing difficulties as 2 or higher on a specific scale.
I have not had any clinical issues in the last three months.
I can read and speak English.
I have a performance status of 3 or lower.
You may not be able to join if
I am currently being treated with a cure in mind for my lung cancer.
I have had my lung cancer get worse in the last three months.
I have a mental condition that prevents me from completing the study.
I am at high risk for fractures or have spine instability.
I have heart failure that is classified as Class II, III, or IV.
I have had a heart problem in the last six months.
I have uncontrolled heart arrhythmias.
I have had a recent serious lung or blood clot issue.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
This study is for people who have previously been diagnosed with advanced stage non-small cell lung cancer (NSCLC). Many people with advanced stage NSCLC have trouble breathing and feel tired. People may be eligible for this study if they have advanced stage NSCLC and feel short of breath some of the time. NSCLC survivors may also experience things like fatigue and a lower quality of life. Pulmona…
This study is for people who have previously been diagnosed with advanced stage non-small cell lung cancer (NSCLC). Many people with advanced stage NSCLC have trouble breathing and feel tired. People may be eligible for this study if they have advanced stage NSCLC and feel short of breath some of the time. NSCLC survivors may also experience things like fatigue and a lower quality of life. Pulmonary rehabilitation is a type of supportive treatment that may improve these symptoms.
This study has two parts. The first part is a randomized trial where half of the participants receive eight weeks of pulmonary rehabilitation. The other half of participants do not do pulmonary rehabilitation and instead receive the treatment that their doctors would normally recommend. The purpose of this part of the research study is to understand if pulmonary rehabilitation can help people with advanced stage NSCLC have better functioning and less shortness of breath.
The other part of the research study is an interview study. The purpose of doing interviews is to understand any challenges or obstacles that people with advanced stage NSCLC may have regarding pulmonary rehabilitation, as well as oncology care providers have with their participants going to pulmonary rehabilitation.
Trial Locations
Loading…
Loading trial locations…
Facility
City
State
Country
Status
Eligibility Criteria
Inclusion Criteria:
* Participants must have histologically confirmed NSCLC, Stages III or IV treated with palliative intent
* Adults ≥ 18 years of age
* ECOG performance status ≤ 3
* Clinical stability: defined as no clinical/radiographic progression within the last three months
* Self-reported dy…
Inclusion Criteria:
* Participants must have histologically confirmed NSCLC, Stages III or IV treated with palliative intent
* Adults ≥ 18 years of age
* ECOG performance status ≤ 3
* Clinical stability: defined as no clinical/radiographic progression within the last three months
* Self-reported dyspnea, defined as score ≥ 2 on the modified Medical Research Council (mMRC) Dyspnea Scale
* Participants must be fluent in written and spoken English
Exclusion Criteria:
* Participants being treated with curative intent for locally advanced NSCLC or oligometastatic NSCLC with concurrent chemotherapy and radiation will be excluded
* Participants have evidence of clinical and/or radiographic progression
* Mental impairment leading to inability to complete study requirements
* High risk of fracture or spine instability (Mirels score ≥7 or SINS ≥7)
* Any of the following cardiac exclusion criteria:
* Class II, III or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system
* History of acute coronary syndromes (including myocardial infarction and unstable angina), coronary angioplasty or stenting within the past 6 months prior to the start of radiation therapy
* Uncontrolled arrhythmias; individuals with rate-controlled atrial fibrillation for \> 1 month prior to start of radiation therapy may be eligible
* Syncope
* Acute myocarditis, pericarditis, or endocarditis
* Acute pulmonary embolus or pulmonary infarction within the last 3 months
* Acute thrombosis of lower extremities within the last 3 months
* Suspected dissecting aneurysm
* Pulmonary edema
* Respiratory failure
* Acute non-cardiopulmonary disorder that may affect exercise performance or be aggravated by exercise
Picking one helps us show the most relevant trials first.
Your results are loading in the background — you can
change this any time from the results page.
Set your location to continue
Find My Trials uses your location to surface clinical trials near you.
Add your city or zip code to your profile and try again.