No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 4
Study type
Interventional
Purpose
Treatment
Participants needed
586 (estimated)
Sponsor
Novo Nordisk A/S · Industry
Who this trial is looking for
This trial is looking for adults with type 2 diabetes who need better blood sugar control. Participants will either use a weekly insulin called icodec or a daily insulin. The trial will last about 13 months.
Are You a Good Fit for This Trial?
Must be takingMetforminSulfonylureasMeglitinidesDPP-4 inhibitorsSGLT2 inhibitorsThiazolidinediones
You may be able to join if
I have been diagnosed with type 2 diabetes for at least 6 months.
I need more help controlling my blood sugar levels.
I have an HbA1c value of 7% or higher within the last 90 days.
I am currently taking certain glucose-lowering medications.
You may not be able to join if
I have a known allergy to the study medications.
I have participated in this study before.
I am pregnant, breastfeeding, or planning to become pregnant.
I have participated in another clinical trial in the last 90 days.
I have a health issue that might put me at risk.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study compares insulin icodec, taken once a week, with other basal insulins, taken once a day, in people with type 2 diabetes.The purpose of this study is to see how well the approved injectable weekly insulin icodec maintains blood sugar levels when compared to approved and available daily injectable basal insulins in people with type 2 diabetes. The participants will either be prescribed we…
This study compares insulin icodec, taken once a week, with other basal insulins, taken once a day, in people with type 2 diabetes.The purpose of this study is to see how well the approved injectable weekly insulin icodec maintains blood sugar levels when compared to approved and available daily injectable basal insulins in people with type 2 diabetes. The participants will either be prescribed weekly insulin icodec or a daily basal insulin (insulin glargine, insulin detemir or insulin degludec) based on current standards for the treatment of type 2 diabetes. The study will last for about 13 months.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Diagnosed with T2D greater than or equal to (≥) 180 days prior to the day of screening.
* Treatment with any of the following non-insulin glucose-lowering medication(s) or combination regimen(s) at the time of screening:
Metformin, Sulfonylureas, Meglitinides (glinides), dipe…
Inclusion Criteria:
* Diagnosed with T2D greater than or equal to (≥) 180 days prior to the day of screening.
* Treatment with any of the following non-insulin glucose-lowering medication(s) or combination regimen(s) at the time of screening:
Metformin, Sulfonylureas, Meglitinides (glinides), dipeptidyl peptidase-4 (DPP-4) inhibitors, sodium-glucose cotransporter-2 (SGLT2) inhibitors, Thiazolidinediones, Alpha-glucosidase inhibitors, Oral combination products (for the allowed individual oral antidiabetic drugs), Oral or injectable glucagon-like peptide-1 (GLP-1) receptor agonists and Injectable dual glucose-dependent insulinotropic polypeptides (GIP) and GLP-1 receptor agonist.
* Need of intensification with basal insulin, as indicated at the discretion of the investigator.
* Recorded HbA1c value ≥7% within the last 90 days prior to randomization.
Exclusion Criteria:
* Known or suspected hypersensitivity to study intervention(s) or related products.
* Previous participation in this study. Participation is defined as signed informed consent.
* Female who is pregnant, breast-feeding or intends to become pregnant or is of child-bearing potential and not using adequate contraceptive method.
* Participation (i.e., received any study intervention) in any interventional clinical study within 90 days before screening.
* Any disorder which in the investigator's opinion might jeopardize participant's safety.
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