Positron Emission Tomography Scan for Multiple Sclerosis
This Study Involves a Positron Emission Tomography (PET) Scan Using a New Investigational Radioactive Tracer, [18F]-FZTA, to Detect Inflammation in the Brain. The Tracer Will be Tested in Healthy Younger Adults and Individuals With Multiple Sclerosis.
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
80 (estimated)
Sponsor
Washington University School of Medicine · Other
Who this trial is looking for
This trial is looking for healthy younger adults and individuals with Multiple Sclerosis. Participants will take part in a PET scan using a new radioactive tracer to help detect inflammation in the brain.
Are You a Good Fit for This Trial?
Rules you outSevere heart failureAdvanced cancerRenal failureLiver failure
You may be able to join if
I am at least 18 years old.
I can provide written consent to participate.
I am healthy or have been diagnosed with Multiple Sclerosis.
You may not be able to join if
I am allergic to the tracer or its components.
I can't safely undergo PET, CT, or MRI scans.
I have severe claustrophobia.
I am pregnant or breastfeeding.
I am currently receiving radiation therapy.
I have had certain heart problems in the last 6 months.
I have taken part in other studies using radioactive substances within the last 12 months.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study involves a Positron Emission Tomography (PET) scan using a new investigational radioactive tracer, \[18F\]-FZTA, to detect inflammation in the brain. The tracer will be tested in healthy younger adults and individuals with Multiple Sclerosis.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Male or female, any race
* Age ≥ 18 years
* Capable of providing written informed consent for volunteering to undergo research procedures.
* Healthy volunteer or volunteer with a diagnosis of MS established using the revised McDonald criteria (2017)
Exclusion Criteria:
* Hyp…
Inclusion Criteria:
* Male or female, any race
* Age ≥ 18 years
* Capable of providing written informed consent for volunteering to undergo research procedures.
* Healthy volunteer or volunteer with a diagnosis of MS established using the revised McDonald criteria (2017)
Exclusion Criteria:
* Hypersensitivity to \[18F\]FZTA or any of its excipients;
* Contraindications to PET, CT, or MRI (e.g., certain incompatible electronic medical devices, inability to lie still for extended periods) that make it potentially unsafe for the individual to participate.
* Severe claustrophobia
* Women who are currently pregnant or breastfeeding
* Currently undergoing radiation therapy
* Any condition that, in the opinion of the Sponsor-Investigator or designee could increase risk to the participant, limit the participant's ability to tolerate the research procedures, or interfere with the collection of the data (e.g., renal or liver failure, advanced cancer);
* Participants who in the last 6 months experienced any of the following cardiovascular conditions or findings in the screening electrocardiogram (ECG): clinically significant cardiac arrhythmias including atrial fibrillation with rapid ventricular response, myocardial infarction, high-grade heart block (type 2 or greater), unstable angina, stroke, transient ischemic attack or decompensated heart failure requiring hospitalization or Class III/IV heart failure;
* Current or recent (within 12 months prior to screening) participation in research studies involving radioactive agents such that the total research-related radiation dose to the participant in any given year would exceed the limits set forth in the U.S. Code of Federal Regulations (CFR) Title 21 Section 361.1.
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