Clinical Study on Immunogenicity and Safety of Lyophilized Vero Cell-Derived Human Rabies Vaccine in Special Populations

Inclusion Criteria: * Subjects with WHO category II or III rabies exposure presenting at the study site for post-exposure prophylaxis and vaccination. * Subjects planned to be included in the control group, aged 18 to less than 60 years old, healthy as confirmed by medical history, physical examination, and clinical judgment before vaccination. * Subjects planned to be included in the study group who meet any of the following conditions: 1. Long-term immunocompromised status due to conditions including, but not limited to: clinically confirmed primary immunodeficiency diseases; hematologic or solid organ malignancies; aplastic anemia; clinically confirmed autoimmune diseases with immunosuppressive therapy lasting 4 weeks or longer within the past 12 months prior to enrollment; history of splenectomy or other major immunologic organ removal; hematopoietic stem cell or solid organ transplantation within 2 years prior to enrollment. 2. Clinically confirmed diabetes mellitus, chronic hepatitis, liver cirrhosis, chronic glomerulonephritis, nephrotic syndrome, or chronic renal insufficiency. 3. Age 60 years or older. * Subjects or their legally authorized representatives are able to understand the study requirements and procedures, voluntarily agree to participate, and sign the informed consent form. * Subjects are able to comply with all planned follow-up visits and provide valid identification documents of themselves and/or their legally authorized representatives. Exclusion Criteria: * History of previous rabies vaccination. * History of human immunodeficiency virus (HIV) infection. * Other conditions deemed unsuitable for participation in the clinical study by the investigator.