Prospective National Cohort Evaluating Prognostic Factors for Efficacy of Fruquintinib Treatment in Patients With Metastatic Colorectal Cancer

Inclusion Criteria: * Patients aged 18 and over. * Histologically confirmed colorectal adenocarcinoma with locally advanced disease and/or unresectable metastasis(es) receiving treatment with fruquintinib under i) compassionate/early access and ii) marketing authorisation and reimbursement in France. * Obtain informed consent from the patient for the clinical-biological cohort. * Agreement to take biological samples of ctDNA and send tumour blocks (patient participation in the pharmacokinetic study remains optional). Exclusion Criteria: * Patient with another concurrent cancer at the time of diagnosis, requiring systemic treatment or influencing prognosis (in the opinion of the centre's medical team). * Contraindication due to psychological or social reasons that may hinder follow-up (cognitive deficit, psychological disorders incompatible with obtaining consent; inability to be followed in the same centre throughout the follow-up period for geographical reasons). * Pregnant or breast-feeding women. * Patients under court protection or subject to a protective measure (patient under guardianship or curatorship).