Acute Effects of Oral Nicotine Pouches

Inclusion criteria (all participants): * greater than or equal to 21 years old * good general health based on screening procedures * vital signs in normal range (resting heart rate less than 110bpm, systolic blood pressure less than 150mmHg, diastolic blood pressure less than 100mmHg) * negative urine test for illicit drug use (excluding THC) and negative breath alcohol test at screening and before each session * no self-reported prior use of oral nicotine pouches * Not actively trying to quit smoking or using smoking cessation medication (e.g., nicotine replacement therapy) Additional inclusion criteria (smokers): * self-report currently smoking cigarettes daily * exhaled breath CO greater than or equal to 10ppm and urine cotinine greater than 100 ng/ml at screening * meet criteria for tobacco use disorder * no self-reported regular use of other tobacco products (e.g., smokeless products, e-cigarettes) in the past 30 days Additional inclusion criteria (non-nicotine users): * self-report previously using nicotine/tobacco but no more than 100 lifetime uses across all routes of administration * no self-reported nicotine/tobacco uses in the past 30 days * urine cotinine less than 100 ng/ml at screening. Exclusion criteria (all participants): * psychoactive drug use (aside from cannabis, nicotine, alcohol, or caffeine) in past month * current use of OTC drugs, supplements/vitamins, or prescription medications that, in the opinion of medical staff, will impact safety * currently have severe dependence for cannabis * history of or current significant medical condition that, in the opinion of medical staff, will impact safety * current psychiatric condition or substance use disorder (aside from tobacco use disorder for smokers), that, in the opinion of medical staff, will impact safety * women who are pregnant, planning to become pregnant, or are breast-feeding