Arch-Clamping Technique Under Mild Hypothermia in Treating With Acute Type A Aortic Dissection
Recruiting
N/A
Interventional Study
Acute Type A Aortic Dissection
Hypothermia
Total Aortic Arch Replacement
Frozen Elephant Trunk
Bilateral Antegrade Cerebral Perfusion
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 – 70
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 306 (estimated)
- Sponsor
- Beijing Anzhen Hospital · Other
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About This Trial
The study is a multicenter, three-arm, open-label, randomized, parallel-controlled trial, which plans to enroll 306 participants diagnosed with acute type A aortic dissection (ATAAD) from 7 hospitals in China. All patients receive total arch replacement (TAR) combined with frozen elephant trunk (FET) implantation and are randomized to Group 1 (arch-clamping technique under mild hypothermia), Group…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Aortic CTA confirmed as ATAAD according to the 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease;
2. Adult patients (18-70 years) weighing 50-120 kg;
3. Time interval between the onset of symptoms and operation is less than 14 days;
4. Indications for …
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