No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
0 and older
Sex
Any
Study type
Observational
Participants needed
550 (estimated)
Sponsor
Tempus AI · Industry
Who this trial is looking for
This trial is looking for patients diagnosed with Acute Myeloid Leukaemia or Follicular Lymphoma. Participants will provide blood samples and leftover tissue during routine treatment to help study their conditions over time.
Are You a Good Fit for This Trial?
You may be able to join if
I am willing to participate and provide blood samples.
I can give informed consent.
I have been diagnosed with Acute Myeloid Leukaemia.
I have been diagnosed with Follicular Lymphoma.
You may not be able to join if
I cannot follow the study procedures.
I have received prior standard therapy for Acute Myeloid Leukaemia.
I have received prior treatment for Follicular Lymphoma.
I am diagnosed with High Risk Follicular Lymphoma.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The TEMPUS AQUARIUS Study is a non-interventional, longitudinal observational study focused on hematological malignancies. It will collect rich molecular (multi-omic) and clinical data from patient cohorts through serial blood draws and the acquisition of leftover tissue and/or bone marrow aspirates during their routine therapy and disease monitoring. The primary goal is to understand the associat…
The TEMPUS AQUARIUS Study is a non-interventional, longitudinal observational study focused on hematological malignancies. It will collect rich molecular (multi-omic) and clinical data from patient cohorts through serial blood draws and the acquisition of leftover tissue and/or bone marrow aspirates during their routine therapy and disease monitoring. The primary goal is to understand the association between biomarkers and real-world clinical outcomes in these patient populations.
Trial Locations
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Status
Eligibility Criteria
All Cohorts Inclusion Criteria:
1. Willing and able to participate in the research and provide biospecimens
2. Willing and able to provide informed consent
Cohort 001 Inclusion:
1. Have documented diagnosis of AML according to the World Health Organization (WHO) classification
2. Secondary AML is…
All Cohorts Inclusion Criteria:
1. Willing and able to participate in the research and provide biospecimens
2. Willing and able to provide informed consent
Cohort 001 Inclusion:
1. Have documented diagnosis of AML according to the World Health Organization (WHO) classification
2. Secondary AML is allowed
Cohort 002 Inclusion:
1. Histologically confirmed diagnosis of Follicular Lymphoma (Subgroups A-D)
2. Submission of baseline sample representative of current disease per laboratory manual (Subgroups A-D)
3. 002A (Newly Diagnosed Active Observation): On active observation for 6 more or less, or intended for active observation
4. 002B (Newly Diagnosed, High Risk): Intended for first line treatment
5. 002B (Newly Diagnosed, High Risk): Meets the criteria for high risk by any of the following: Follicular Lymphoma Inernational Prognostic Index (FLIPI) High Risk, Groupe d'Etude des Lymphomes Follicularies (GELF) High Tumor Burden, Lactate Dehydrogenase (LDH) above the upper limit of normal (ULN)
6. 002C (Relapsed / Refractory High Risk POD24 FL): Documented progression of disease within 24 months (POD24) of first line follicular lymphoma treatment, prior to second line treatment
7. 002D (Transformed FL): Pathologically confirmed transformation
All Cohorts Exclusion Criteria:
1\. Not willing or able to adhere with the study procedures
Cohort 001:
1\. Have received any prior therapy intended for standard of care (SoC) treatment of AML
Cohort 002:
1. 002A: Received prior treatment for follicular lymphoma
2. 002A: Diagnosed with High Risk follicular lymphoma by any of the following definitions: FLIPI High Risk, GELF High Tumor Burden, LDH above ULN
3. 002A: Resected patients with NED
4. 002B: Intended for active observation
5. 002B: Received prior treatment for follicular lymphoma
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